Subject: Basic medicine
Year: 2024
Type: Conference or Workshop Item
Type: NonPeerReviewed
Title: Exploring the Electrochemistry of Surface-Active Redox Systems in Voltametric Analysis of Drug-Drug Interactions
Author: Lazarova, Sanja
Author: Janeva, Milkica
Author: Kokoskarova, Pavlinka
Abstract: Methylene blue is a model-like surface-active redox system, suitable to study various effects related to chemical interactions involved in voltammetry of surface electrode mechanisms. The redox transformation of methylene blue (MB) described by 2e-/2H+, whereby MB switches between the oxidized form (blue-MB) to a reduced form called leuko-methylene blue (MBH2).1 The voltammetric patterns of methylene blue can be analyzed in a way to get access to thermodynamics and kinetics of eventual interactions between MB/MBH2 and a defined drug. By applying suitable theoretical models developed under square wave voltammetry, it is possible to evaluate the mechanism, and also kinetic and thermodynamic parameters of interaction between given drug and the electroactive molecules of MB. In experimental protocol, all parameters are kept constant and only concentration of the drug changes.2 Experimental Results: (A) Net SW voltammograms of methylene blue recorded in absence and in presence of ibuprofen, (B) Net-SW voltammograms of methylene blue recorded in absence of vitamin and in presence of vitamin C. Keywords: voltammetry, kinetics, thermodynamics, drug-drug interactions.
Publisher:
Relation: https://eprints.ugd.edu.mk/35813/
Identifier: oai:eprints.ugd.edu.mk:35813
Identifier: https://eprints.ugd.edu.mk/35813/1/27-th%20Congress%20Book%20of%20Abstracts-Sanja%20Lazarova.pdfIdentifier: https://eprints.ugd.edu.mk/35813/2/Presentation-poster-Sanja%20Lzarovapdf.pdfIdentifier: Lazarova, Sanja and Janeva, Milkica and Kokoskarova, Pavlinka (2024) Exploring the Electrochemistry of Surface-Active Redox Systems in Voltametric Analysis of Drug-Drug Interactions. In: Сојуз на хемичарите и технолозите на Македонија Society of Chemists and Technologists of Macedonia, 25–28 Sept 2024, Ohrid. (Unpublished)
